Post-Exposure Prophylaxis (PEP)

August 2016: The Second edition of the Post-Exposure Prophylaxis after Non-Occupational and Occupational Exposure to HIV: Australian National Guidelines is available.

These guidelines outline the management of individuals who have been exposed (or suspect they have been exposed) to HIV in non-occupational and occupational settings. There are currently no data from randomised controlled trials of the use of post-exposure prophylaxis (PEP) and evidence for use has been extrapolated from animal data, mother to child transmission, occupational exposure and small prospective studies of PEP regimens in HIV-negative men. Accordingly, assumptions are made about the direction of management.

Every presentation for PEP should be assessed on a case-by-case basis, balancing the potential harms and benefits of treatment.

Recommendations following non-occupational exposure have been updated, and information about PEP in the context of pre-exposure prophylaxis (PrEP), PEP and children, renal disease, and gender identity and history has been added.

Visit the Website Version of the Guidelines

Download the Guidelines

Post-Exposure Prophylaxis after Non-Occupational and Occupational Exposure to HIV: Australian Guidelines (2016)

Download the Literature Review

PEP Literature Review (2016)

Download the Informational Poster

Post-Exposure Prophylaxis for HIV – What Else to Consider?

Related documents

To support you with the implementation of these guidelines the following template documents have been prepared as part of the 2016 review. The Expert Reference Group for the guidelines thanks the staff at the Western NSW LHD and St Vincent’s Hospital in Sydney, for providing their materials for adaptation for this purpose.

Please note: these resources are provided as templates for adaptation in line with local protocols. Finalised content is the responsibility of local staff.

PEP Checklist

NPEP Procedure Flowchart Template

NPEP Patient Information Sheet

NPEP Referral Letter Proforma