Australasian Society for HIV Medicine

Professor Bernard Hirschel (Division of Infectious Diseases Geneva University Hospital Geneva, Switzerland) gave a lecture titled 'Highly Active Antiretroviral Therapy (HAART) and Contagiousness' at the Garvan Institute of Medical Research Sydney on 18th March 2008. Feedback from the lecture was positive. The lecture covered the following areas of HAART and contagiousness in terms of:

• The relation between viremia and contagiousness without treatment
• Effects on viremia and contagiousness with HAART
• Conclusions to draw (or not) for the individual
• Possible consequences for the epidemic
• Background to the "Swiss Statement"

The Power Point presentation from this lecture is available on the ASHM website (HAART and Contagiousness). If you would like further information from the references sited in the presentation please follow the links listed below.

References and links

(Slide 5) Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, Meehan MO, Lutalo T, Gray RH. (2000) Viral Load and Heterosexual Transmission of Human Immunodeficiency Virus Type 1 N Engl J Med 2000;342:921-9
Reference link: http://content.nejm.org/cgi/content/full/342/13/921

(Slide 6) Garcia PM, Kalish LA, Pitt J, Minkoff H, Quinn TC, Burchett SK, Kornegay J, Jackson B, Moye J, Hanson C, Zorrilla C, Lew JF. (1999) Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group. N Engl J Med. Aug 5; 341(6):394-402.
Reference link: http://content.nejm.org/cgi/content/short/341/6/394?query=nextarrow

(Slide 8) May MT, Sterne JA, Costagliola D, Sabin CA, Phillips AN, Justice AC, Dabis F, Gill J, Lundgren J, Hogg RS, de Wolf F, Fätkenheuer G, Staszewski S, d'Arminio Monforte A, Egger M; Antiretroviral Therapy (ART) Cohort Collaboration. (2006) HIV treatment response and prognosis in Europe and North America in the first decade of highly active antiretroviral therapy: a collaborative analysis Lancet. 2006 Aug 5; 368(9534):427-8.
Reference link:
http://www.thelancet.com/journals/lancet/article/PIIS0140673606691526/abstract

(Slide 10) Vernazza PL, Troiani L, Flepp MJ, Cone RW, Schock J, Roth F, Boggian K, Cohen MS, Fiscus SA, Eron JJ. (2000) Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. The Swiss HIV Cohort Study. AIDS 2000, 14:117±121
Reference link: http://www.aidsonline.com/pt/re/aids/abstract.00002030-200001280-00006.htm;jsessionid=HppB357R3NRJyDdhkSgcznLQqBnGhs51y13TY2tg4JR5yM6fL5D6!923867264!181195629!8091!1?index=11&database=ppvovft&results=1&count=10&searchid=5&nav=search

(Slide 15) TownsendC, Cortina-Borja M, Peckham C, de Ruiter A, Lyall H, and Tookey P (2008) Very Low Risk of MTCT in Women on HAART Who Achieve Viral Suppression: The UK and Ireland, 2000 to 2006 15th Conference on Retroviruses and Opportunistic Infections, Poster 653
Reference link: http://www.retroconference.org/2008/PDFs/653.pdf

(Slide 16)
(16A) Kilewo C, Karlsson K, Ngarina M, Massawe A, Lyamuya E, Lipyoga R, Msemo G, Swai A, Mhalu F, Biberfeld G (2007) Prevention of mother-to-child transmission of HIV-1 through breastfeeding by treating mothers prophylactically with triple antiretroviral therapy in Dar es Salaam, Tanzania - the MITRA PLUS study IAS Conference Sydney, Abstracts TUAX101
Reference link: http://www.ias2007.org/pag/Abstracts.aspx?SID=52&AID=2984

(16b) Arendt V, Ndimubanzi P, Vyankandondera J, Ndayisaba G, Muganda j, Courteille O, Rutanga C, Havuga E, Dhont N, Mujawamassiga A, Omes C, Peltier A. (2007) AMATA study: effectiveness of antiretroviral therapy in breastfeeding mothers to prevent post-natal vertical transmission in Rwanda IAS Conference Sydney, Abstracts TUAX101
Reference link: http://www.ias2007.org/pag/Abstracts.aspx?SID=52&AID=5043

(Slide 23) Castilla J, Del Romero J, Hernando V, Marincovich B, García S, Rodríguez C. (2005) Effectiveness of highly active antiretroviral therapy in reducing heterosexual transmission of HIV JAIDS; 40:96-101
Reference link: http://www.ncbi.nlm.nih.gov/sites/entrez

(Slide 25)
(25a) Wawer M et al. (2008) Trial of circumcision in HIV+ men in Rakai, Uganda: effects in HIV+ men and women partners. Fifteenth Conference on Retroviruses and Opportunistic Infections, Boston. Abstract 33LB.
Reference link: http://www.aidsmap.com/en/news/CA7B4AB2-765A-4AAC-A08F-A0297B44B030.asp
(25b) Bunnell R et al. (2008) 3-year follow-up of sexual behavior and HIV transmission risk of persons taking ART in rural Uganda. Fifteenth Conference on Retroviruses and Opportunistic Infections, Boston, abstract 29.
Reference link: http://www.aidsmap.com/en/news/B3AB61E8-5151-4994-A955-507FD47F8C8C.asp

(Slide 28) Jin F, Prestage G, Ellard J, Kippax S, Kaldor J, Grulich A (2007) A How homosexual men believe they became infected with HIV. JAIDS 46:245-247
Reference link: http://www.jaids.com/pt/re/jaids/abstract.00126334-200710010-00017.htm;jsessionid=Hp2WqNFb0kLGk3byYjvngvZTJTkQSmxlRfH2nxTRPwvZXXpG12xs!923867264!181195629!8091!-1

(Slide 33) Lewontin RC: Sex, Lies, and Social Science The New York Review of Books, Volume 42, Number 7, April 20, 1995
Reference link: http://www.nybooks.com/articles/article-preview?article_id=1923

(Slide 37) Barreiro P et al. Natural Pregnancies in HIV-Serodiscordant Couples Receiving Successful Antiretroviral Therapy. J Acquir Immune Defic Syndr 2006;43:324-326.
Reference link: http://www.jaids.com/pt/re/jaids/pdfhandler.00126334-200611010-00010.pdf;jsessionid=Hp6MjcWvjnmsGDQSnMLVLJjjDrL5b4zg6QNpjctVpXbvTjLfD8yT!923867264!181195629!8091!-1

(Slide 46) Buchacz, J Klausner et al. (2005) Trends in Primary and Secondary Syphilis and HIV Seroincidence among Men Who Have Sex with Men in San Francisco, 1998-2002. CDC, Atlanta, GA, USA, CROI 2005, Presentation No 88 Session 18 Oral Abstracts and Mini-Lectures
Epidemiology of HIV Infection in the United States
Reference link: http://www.retroconference.org/2004/cd/Abstract/88.htm

(Slide 71) Vernazza P et al. Les personnes séropositives ne souffrant d'aucune autre MST et suivant un traitment antirétroviral efficace ne transmettent pas le VIH par voie sexuelle. Bulletin des médecins suisses 89 (5), 2008.
Reference link: http://www.saez.ch/pdf_f/2008/2008-05/2008-05-089.PDF

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