HIV Management in Australasia
Table of Contents
This page contains the table of contents for ASHM monograph titled HIV Management in Australasia.
Chapter 1
Basic HIV virology link
Robert Oelrichs
1.1 HIV structure and organisation 9
1.2 HIV lifecycle 10
1.3 The taxonomy of HIV and the primate immunodeficiency viruses 12
1.4 The global pandemic of HIV 16
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Chapter 2
HIV immunopathology
Mark Kelly
2.1 The cellular immune system 23
2.2 Immunological aspects of HIV pathophysiology 25+
2.3 Highly exposed but persistently seronegative subjects (HEPS) 30
2.4 HIV and escape from specific host immune responses 31
2.5 CD4 cell defects in HIV disease 31
2.6 Other sites of immune dysfunction 33
2.7 Rational for immune-based therapies 34
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Chapter 3
Natural history of HIV infection
Mark Kelly
3.1 Transmission and dissemination 41
3.2 Disease progression 43
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Chapter 4
Diagnostics
4.1 Virological diagnostics 51
Robert Oelrichs
4.2 Immunological diagnostics and therapeutic drug monitoring 56
Mark Kelly, John Ray
Therapeutics and monitoring
Chapter 5
Antiretroviral therapy
Anna Pierce
5.1 Historical perspective 59
5.2 Goals of therapy 59
5.3 Antiretroviral agents 60
Chapter 6
New HIV diagnosis
Olga Vujovic
Chapter 7
Initiation of antiretroviral therapy in the naïve patient
Olga Vujovic
7.1 When to start therapy in the individual with chronic HIV infection 75
7.2 Which regimen to use in the individual with chronic HIV infection 77
7.3 Consideration of antiretroviral therapy in acute HIV infection 79
7.4 Antiretroviral treatment in specific clinical scenarios 81
Chapter 8
Managing the patient on antiretroviral therapy
Olga Vujovic, Anna Pierce
8.1 Monitoring 95
8.2 Adherence 95
8.3 Failure of therapy 96
8.4 Resistance testing 97
8.5 Changing antiretroviral therapy 99
Chapter 9
Approach to management of antiretroviral therapy toxicity
Olga Vujovic
9.1 Mitochondrial toxicity 103
9.2 Hepatotoxicity 105
9.3 Metabolic abnormalities 106
9.4 Bone disease 108
Chapter 10
Strategies to improve treatment outcome
Anna Pierce
10.1 Therapeutic drug monitoring 113
10.2 Experimental treatment strategy approaches 115
10.3 Role of immune-based therapy 116
Chapter 11
Post-exposure prophylaxis
Olga Vujovic
11.1 Occupational exposure to HIV infection 119
11.2 Non-occupational exposure to HIV infection 120
11.3 Public health guidelines 121
Clinical manifestations of HIV disease
Chapter 12
Clinical manifestations and the natural history of HIV
Cassy Workman
12.1 Acute primary illness 123
12.2 Asymptomatic/early infection 125
12.3 Symptomatic/intermediate infection 126
12.4 Late-stage disease 127
12.5 Late presentation 127
12.6 Natural history in the HAART era 128
Chapter 13
Key opportunistic infections 131
13.1 Pneumocystis carinii 131
Jeffrey J Post
13.2 Kaposi's sarcoma 136
Cassy Workman
13.3 Oesophageal candidiasis 138
Mark Kelly
13.4 Mycobacterium avium complex 142
Jeffrey J Post
13.5 Mycobacterium tuberculosis 146
Jeffrey J Post
13.6 Toxoplasmosis 148
Kate Clezy
13.7 Cryptococcosis 151
Kate Clezy
13.8 Cryptosporidiosis 154
Mark Kelly
13.9 Cytomegalovirus 156
Mark Kelly
13.10 Microsporidiosis 161
Mark Kelly
Chapter 14
Respiratory manifestations 163
14.1 Approach to respiratory symptoms 163
Jeffrey J Post
14.2 Respiratory infections 166
Cassy Workman
14.3 Respiratory disorders 171
Jeffrey J Post
Chapter 15
Gastrointestinal manifestations 175
15.1 Approach to gastrointestinal symptoms 175
Jeffrey J Post
15.2 Gastrointestinal and oral infections 178
Mark Kelly
Chapter 16
Dermatological manifestations 189
Mark Kelly, Cassy Workman
16.1 Approach to dermatological infections 189
16.2 Varicella-zoster virus 189
16.3 Herpes simplex virus 191
16.4 Scabies 193
16.5 Molluscum contagiosum 193
16.6 Oral and anogenital warts 194
16.7 Seborrhoeic dermatitis 195
Chapter 17
Oncological conditions 199
Cassy Workman
17.1 Non-Hodgkin's lymphoma 199
17.2 Hodgkin's disease 201
17.3 Cervical cancer 202
17.4 Anal cancer 203
17.5 Lung cancer 204
17.6 Other cancers 204
Chapter 18
Neurological conditions 209
18.1 Approach to neurological conditions 209
Jeffrey J Post
18.2 Neurological disorders in HIV/AIDS 210
Edwina J Wright, Catherine L Cherry, Bruce J Brew
18.3 Progressive multifocal leukoencephalopathy 218
Edwina J Wright, Bruce J Brew
Chapter 19
Constitutional or systemic infections 223
19.1 Approach to systemic symptoms in HIV infection 223
Jeffrey J Post
19.2 Infections to consider in presence of constitutional symptoms 226
Cassy Workman
Chapter 20
Other diseases or disorders 235
20.1 Cardiovascular disease 235
Adam Jenney
20.2 Renal disorders 237
Jeffrey J Post
20.3 Psychiatry and HIV 239
Cassy Workman
20.4 Rheumatological disease 244
Adam Jenney
20.5 Endocrine disorders 247
Jeffrey J Post
Chapter 21
Coinfections 251
21.1 Hepatitis B coinfection 251
Joe Sasadeusz
21.2 Hepatitis C coinfection 256
Jeffrey J Post
21.3 HIV and syphilis 262
Mark Kelly
Chapter 22
Immune restoration diseases 267
Mark Kelly
22.1 Immunological aspects of immune reconstitution 267
22.2 Immune restoration disease 267
22.3 Ceasing prophylaxis for opportunistic infections 271
Appendixes 275
Acronyms 279
Index 283
More information
Please contact ashm@ashm.org.au
